年轻妇女子宫内膜癌临床分析

Clinical Analysis of Endometrial Carcinoma in Young Women

目的探讨年轻妇女子宫内膜癌的临床病理特征、诊治方法及预后。方法回顾性分析我院收治的45岁以下年轻妇女子宫内膜癌21例资料。结果本组21例占同期收治子宫内膜癌的13．9％，与以往资料相比，患者有年轻化趋势；≤40岁者和41-45岁者在临床分期、细胞分化、病理类型及肌层浸润深度方面比较差异无统计学意义（P〉0．05）；21例均行手术治疗，术后随访6个月-15年，其中失访2例，死亡2例，复发3例。结论45岁以下年轻妇女子宫内膜癌临床期别较早，病理类型主要为子宫内膜样腺癌，分段诊刮是其诊断的有效方法，治疗以手术为主，对合并高危因素者辅以放、化疗。

Objective To study the clinicopathological characteristics, diagnosis, treatment and prognosis of endometrial carcinoma in young women under 45 years old. Methods Retrospective analyses of clinical data of 21 patients with endometrial carcinoma in young women under 45 years old were done. Results 13.9 % of the patients were under 45 years old. There was trend that endometrial carcinoma was harassing younger women, as compared with the old data in our hospital （ P 〈 0.05 ）. There was no significant difference between the patients of two groups in clinical stage, cell differentiation, pathologic type and depth of myometrial infiltration （ P 〉 0.05 ）. The mean time of follow-up were six months to 15 years, 2 cases lost contact, 2 cases died, 3 cases reoccurred among the 21 cases received surgical procedures. Conclusion In the patients with endometrial carcinoma under 45 years of age, the clinical stage is earlier and major pathologic type is endometrioid adenocarcinoma. Fractional curettage of the uterus is an effective method to diagnose this carcinoma. Surgical operation is an effective treatment for it. Radiotherapy and chemotherapy are suitable for the patients with high risk factors.