非洛地平联合阿托伐他汀钙对颈动脉内-中膜厚度的影响

The Effect of Combination of Felodipine and Atorvastatin on Carotid Artery Intima-media the Thickness in Essential Hypertension

目的:研究非洛地平联合阿托伐他汀钙对高血压颈动脉内-中膜厚度(IMT)的影响。方法:将原发性高血压患者84例,随机分为实验组42例和对照组42例,对照组使用非洛地平5mg,1次/d,实验组在对照组基础上,加用阿托伐他汀钙20mg,1次/晚,治疗12个月,比较两组IMT,血压,空腹血糖及血脂水平。结果:实验组治疗12个月后,颈动脉IMT、收缩压、TG、TC、LPL-C均显著降低,治疗后的IMT与治疗前及与对照组治疗后的IMT比较,差异均有统计学意义(P<0.05)。两组间血糖、心率比较差异无统计学意义。结论:高血压患者服用非洛地平联合阿托伐他汀钙治疗能更好地延缓IMT进展。

Objective ： To study the effect of combination of Felodipine and atorvastatin on carotid artery intima - media thickness （IMT） in patients with essential hypertension. Methods：Eighty -four patients with essential hypertension were randomly divided into test and control groups. The control group was treated with Felodipine and the test group was treated with atorvastatin 20mg every night in addition to Felodipine for twelve months. The differences were observed between two groups. Results： After twelve months of therapy, in test group, carotid artery IMT, systolic blood pressure, diastolic blood pressure, serum triglyeeride, total cholesterul and low - density lipoprotein cholesterol significantly decreased. There were significant difference pre - treatment and after treatment, and significant differences between test group and control group. Conclusion ： The combination of Felodipine and atorvastatin can delay increase in carotid artery intima - media thickness of patients with essential hypertension.