低氧、气功对模拟失重人体尿丙二醛、血超氧化物歧化酶及循环内皮细胞的影响

Effects of Hypoxia and Qigong on Urine Malondialdehyde,Superoxide Dismutase and Circulating Endothelial Cell in Humans during Simulated Weightlessness.

为研究模拟失重、低氧、气功及其复合作用对人体脂质过氧化及循环内皮细胞含量（ＣＥＣ）的影响，受试者为１５名１９～２１岁男性健康青年，分为单纯卧床组（ＷＣ）、卧床＋低氧组（ＷＨ）和卧床＋气功组（ＷＱ）进行了１７ｄ的头低位－６°卧床实验。结果显示：（１）ＷＣ组随卧床模拟失重时间延长，血超氧化物歧化酶（ＳＯＤ）活性显著增加，尿丙二醛（ＭＤＡ）含量显著降低，与ＷＣ组相比，ＷＨ组卧床１７ｄ的血ＳＯＤ活性增加，ＷＱ组卧床７ｄ的血ＳＯＤ活性降低，而ＷＨ和ＷＱ组的ＭＤＡ无显著变化。表明时失重机体抗氧化能力增强，脂质过氧化水平降低，低氧、气功在卧床时对机体的ＳＯＤ的活性有一定的影响。（２）ＷＣ组在卧床７ｄ时ＣＥＣ含量显著下降，在１７ｄ时恢复正常，表明机体在卧床条件下血ＣＥＣ含量有一定的变化。提示：低氧对卧床机体的血ＣＥＣ含量无明显影响。

Changes of lipid hyperoxidation and amount of circulating endothelial cells under simulated weightlessness and factors that may influence these changes were observed in 3 groups of subjects (5 in each group) exposed to 17d -6° head down bed rest (HDBR), HDBR+hypoxia and HDBR+qigong respectively.The results showed:(1)simple HDBR promotes antioxidation activity and attenuates hyperoxidation of lipids,and hypoxia and Qigong have some influence on the former but not on the latter;(2)circulating endothelial cells decreased significantly after simple HDBR for 7 d but recovered to normal when HDBR continued for 17 d.Hypoxia showed no influence on this effect while Qigong alleviated it significantly.It suggests that (1)both hypoxia and Qigong have some influence on the promotion of antioxidation activity but have no influence on the production of oxygen free radicals.(2)Qigong shows some antagonistic effect against the attenuation of circulating endothelial cells by HDBR.