摘要
Biocompatibility of dental porcelain is of crucial importance to the long-term success of dental prostheses because of its close contact with oral tissues for extended periods. This investigation was aimed to evaluate cellular responses to locally produced dental porcelain （Universiti Sains Malaysia, Malaysia） after a short-term subcutaneous implantation in a rat model. Locally produced dental porcelains supplied in disc form were implanted subcutaneously into 12 Sprague-Dawley male albino rats, which were sacrificed in groups of 3 at 1, 2, 3 and 4 weeks after implantation. A semi-quantitative histological analysis of the tissue surrounding implanted discs was done under an image analyzer after staining with hematoxyline and eosin. The macrophage was clearly the dominant cell type at the implant surface at the first week after implantation, followed by a gradual decrease as the implantation period increased. On the contrary, fibroblasts and fibrocytes were the dominant cell types in the tissue surrounding the implanted discs at the third and fourth week after implantation with the appearance of mature collagen. From pathological point of view, the disappearance of inflammatory cellular responses and the well matured fibrous connective tissue surrounding the implanted discs indicate a satisfactory in vivo biocompatibility.
