MCP-1、RANTES检测对结核性胸腔积液的诊断价值

The diagnostic value of MCP-1 and RANTES in tuberculosis and malignant pleural effusion

目的测定胸腔积液中趋化因子MCP-1、RANTES的水平，探讨对结核性胸腔积液的诊断价值。方法测定结核性胸腔积液（结核组）37例，癌性胸腔积液（癌性组）35例，健康人20例（对照组）的血清及胸腔积液MCP-1、RANTES值。结果结核组患者血清及胸腔积液中的MCP-1和RANTES水平显著高于癌性组（P〈0．01）；结核组血MCP-l值明显高于对照组（P〈0．01），而结核组RANTES值于对照组无显著差异（P〉0．05）：MCP-1和RANTES水平与肺癌的病理类型元关。结论胸腔积液中MCP-1和RANTES检测对结核性和癌性胸腔积液的鉴别有较高的临床意义。

Objective To determin and compare the significance of the expression of chemotactic cytokines in pleural effusions monocyte chemoattraetant protein-1 （MCP-1）and regulated on activation,normal ,T-cell expressed and secreted（RANTES） levels in tuberculous and malignant pleural effusions. Methods The effusion and serum levels of MCP-1 and RANTES were measured in 37 patients with tuberculous pleural effusion and 35 patients with malignant pleural effusion, and selected 20 healthy people acting as control group. Results The effusion and serum levels of MCP-1 and RANTES in tuberculous effusion patients was significantly higher than that in malignant group （ P 〈 0. 01 ） ; In tuberculous group, the content of MCP-1 in serum was higher than control group, the serum level of RANTES was no statistic significant difference between control group and tuberculous group. The contents of MCP-1 and RANTES were not correlated with pathologic type of lung cancer. Conclusion MCP-1 and RANTES technique has an important clinical value in diagnosis and differential diagnosis of tuberculosis and malignant pleural effusion.