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芳香化酶在人类乳腺癌、睾丸癌发生过程中的作用 被引量:5

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摘要 芳香化酶由细胞色素P450芳香化酶和NADPH-细胞色素P450还原酶组成,能够催化雌激素的合成及雄激素A环的羟化。目前研究发现,与非转基因鼠相比,芳香化酶转基因小鼠乳腺组织及睾丸组织中芳香化酶的过表达能引起相应部位雌激素的升高,进而引起乳房增生及睾丸增生,从而导致人类乳腺癌和睾丸癌的发生。
出处 《实验动物科学》 2009年第6期62-63,共2页 Laboratory Animal Science
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