摘要
Pin1是人类肽基脯氨酰顺反异构酶,能特异性地识别、结合磷酸化的丝氨酸/苏氨酸-脯氨酸基序,催化肽的顺反异构,改变蛋白质的构象,影响其活性和稳定性。阿尔茨海默病中发生病理性改变的蛋白质(如过度磷酸化的微管相关蛋白tau和磷酸化的淀粉样前体蛋白等)都含有丝/苏氨酸模体。它们的活性和功能均受Pin1的变构调节。Pin1与神经元的凋亡也有关系,对神经元具有保护效应。
The pin 1 ,as a human peptidyl-prolyl cis-trans isomerase,can specifically bind with phosphorylated sefine/threonine-Pro protein motifs and catalyze the cis-trans isomerization of the peptide bond, change protein conformation and influence the stability and activity of proteins. Most of the proteins showing pathological changes in Alzheimer disease carry serinc/threonine motifs, their activity and function are governed by Pinl. Pinl is also related to neuronal apoptosis with a protective effect on neurons.
出处
《医学综述》
2010年第3期404-406,共3页
Medical Recapitulate
