紫外分光光度法测定抗癌药物来曲唑的含量

Determination of the Anti-cancer Drug of Letrozole by UV Spectrophotometry

建立了紫外分光光度法测定药物来曲唑含量的方法。在乙腈溶液中，来曲唑的最大吸收波长在240nm处，摩尔吸收系数为3．396×10^4L·mol^-1·cm^-1，来曲唑的浓度在2．89×10^-6～2．31×10^-5mol／L范围内吸光度与浓度呈良好的线性关系。该方法操作简单，重现性好，准确，用于来曲唑片剂含量的测定，结果满意。

A new method for the determination of letrozole by UV spectrophotometry was developed. Using acetonitrile as solvent and 240 nm measuring wavelength, the absorbance is proportional to the concentration of letrozole in the range of 2. 888 ×10^-6～ 2. 310 ×10^-5 mol/L. The method was quite simple, reproducible, accurate and reliable. It is applicable to the determination of the content of letrozole in tablet.