清降胶囊对肾实质性高血压患者血浆内皮素及血浆一氧化氮的影响

Effect of QingJiang capsule on Endothelin (ET) and Nitric Oxide (NO) in Serum of Patients with Renal Parenchymal Hypertension

目的:观察清降胶囊对肾实质性高血压患者血浆内皮素及血浆一氧化氮的影响。方法:入选病例62例,随机分为治疗组和对照组,观察2组血浆内皮素及血浆一氧化氮的变化。结果:治疗组治疗后血浆内皮素(ET)较治疗前明显下降(P<0.05),血浆一氧化氮(NO)较治疗前明显升高(P<0.05)。结论:清降胶囊治疗肾实质性高血压作用机理与该方有效抑制血浆内皮素(ET)的生成及调节一氧化氮(NO)的释放有关。

Objective： To observe the effect of QingJiang capsule on ET and No in serum of patients with renal parenchymal hypertension. Methods： 62 cases randomly divided into treatment group and control group. The level of ET and No in serum of the two groups was detected. Results： After treatment, the ET level of the treatment group significant- ly decreased compared with before treatment （P〈0.05）.The level of NO was significantly higher than that before treat- ment （P〈0.05）. Conclusion： The QingJiang capsule had special effects to treating renal parenchymal hypertension. The mechanisms may be inhibit ET formation and adjust the release of NO.