地榆升白片预防性治疗干扰素所致白细胞减少的临床观察

Clinical effect of Diyu Shengbai Tablet on preventive treatment of leukopenia by IFN

目的:观察地榆升白片预防性治疗干扰素所致白细胞减少的临床疗效。方法:112例干扰素治疗慢性乙型肝炎患者,随机分为地榆升白片组、利血生组,分别于干扰素治疗前7 d开始服用地榆升白片或利血生,然后检测每组患者干扰素治疗后3 d、7 d、10 d、14 d、28 d的外周血细胞数值,观察地榆升白片预防性用药患者的血细胞数值的变化情况。结果:干扰素治疗3 d两组患者的外周血中性粒细胞均数分别为(1.91±0.56)×109/L、(1.48±0.55)×109/L,白细胞均数分别为(3.91±0.33)×109/L、(3.16±0.49)×109/L,其间差异有统计学意义(P<0.05)。结论:地榆升白片预防性用药对于治疗干扰素所致白细胞减少有效,地榆升白片治疗是一种安全、经济、方便的预防干扰素所致白细胞减少的有效药物。

AIM： To observe effect of Diyu Shengbai Tablet on preventive treatment for interferon-induced leu- kopenia. METHODS： One hundred and twelve patients with chronic hepatitis B treated by IFN were randomly assigned into two groups, and they were respectively treated with Diyu Shengbai Tablet and Leucogen for 7 days before treatment by IFN. The leukocyte count of each group was done in 3 days,7 days, 10 days, 14 days,28 days after treatment by IFN. Comparison was made on the value of leukocytes between two preventive treatment groups. RESULTS： In the third day after treatment by IFN the value of ANC were（ 1.91 ±0.56） ×10^9/L, （ 1.48 ±0.55） ×10^9/L respectively. The value of leukocytes were （3.91 ± 0.33 ） ×10^9/L, （3. 16 ±0.49） ×10^9/L respectively. They had the statistical difference （P 〈 0.05 ）. CONCLUSION ： Diyu Shengbai Tablet has an effect on preventing lekopenia induced by IFN, and it is a safe, cheap and convenient drug to treat leucopenia by IFN.