摘要
在超声波辐射下,端基炔与叠氮基(3,3-二甲基-2,4-二氧戊环基)甲烷通过1,3-偶极环加成合成了1-(3,3-二甲基-2,4-二氧戊环基甲基)-4-芳基-1,2,3-三唑(5);5在酸性条件下脱保护得1-(2,3-二羟基丙基)-4-芳基-1,2,3-三唑,其结构经1H NMR,13C NMR,MS和元素分析表征。
1-(3,3-Dimethyl-2,4-dioxolaneyl-methyl) -4-aryl-1,2,3-triazole ( 5 ) was synthesized by 1, 3-dipolar cycloaddition of 3,3-dimethyl-2,4-dioxolaneyl-methyl azide and terminal alkyne under ultrasound irradiation for 20 rain. The hydroxyl protection of 5 was removed in acidic solution to obtain 1 - (2,3-dihydroxylpropyl) -4-aryl-1,2,3-triazole. The structures were characterized by ^1H NMR, ^13 C NMR, MS and elemental analysis.
出处
《合成化学》
CAS
CSCD
北大核心
2010年第1期56-60,共5页
Chinese Journal of Synthetic Chemistry
基金
中国科技部863计划资助项目(2006AA100216)