1,4-二取代-1,2,3-三唑衍生物的合成

Synthesis of 1,4-Disubstituted-1,2,3-triazole Derivatives

在超声波辐射下,端基炔与叠氮基(3,3-二甲基-2,4-二氧戊环基)甲烷通过1,3-偶极环加成合成了1-(3,3-二甲基-2,4-二氧戊环基甲基)-4-芳基-1,2,3-三唑(5);5在酸性条件下脱保护得1-(2,3-二羟基丙基)-4-芳基-1,2,3-三唑,其结构经1H NMR,13C NMR,MS和元素分析表征。

1-（3,3-Dimethyl-2,4-dioxolaneyl-methyl） -4-aryl-1,2,3-triazole （ 5 ） was synthesized by 1, 3-dipolar cycloaddition of 3,3-dimethyl-2,4-dioxolaneyl-methyl azide and terminal alkyne under ultrasound irradiation for 20 rain. The hydroxyl protection of 5 was removed in acidic solution to obtain 1 - （2,3-dihydroxylpropyl） -4-aryl-1,2,3-triazole. The structures were characterized by ^1H NMR, ^13 C NMR, MS and elemental analysis.