摘要
研究了1-(1-萘基)乙胺[(RS)-1]和1-(2-萘基)乙胺[(RS)-2]的循环拆分方法。以D-酒石酸为拆分剂,分别拆分(RS)-1和(RS)-2得到了(R)-1-(1-萘基)乙胺(收率31%,98%ee)和(R)-1-(2-萘基)乙胺(收率30%,98%ee),并对母液中的非目标对映异构体成功的进行了消旋化,实现了循环拆分。
The recycling resolution of (RS) -1 - ( 1 -naphthyl ) ethylamine [ ( RS ) -1 ] and ( RS ) -1 - ( 2 - naphthyl) ethylamine [ (RS) -2 ] was studied in this paper. (R) -1 - ( 1 -naphthyl ) ethylamine ( 31% yield, 98%ee) and (R)-1-(2-naphthyl) ethylamine(30% yield, 98% ee) were obtained via resolution of the racemic (RS) -1 and (RS) -2 by using D-tartaric acid as a resoluting agent. Meanwhile racemization of the non-target enantiomeric isomers from mother liquor was performed, and the recycling resolution was realized.
出处
《合成化学》
CAS
CSCD
北大核心
2010年第1期61-63,共3页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(20972048)
上海市教育发展基金资助项目(03SG27)
关键词
萘乙胺
拆分
循环拆分
消旋
naphthylethylamine
resolution
recycling resolution
racemization