不同临床类型强迫症患者脑脊液单胺类神经递质对照研究

A control study of CSF monoamine neurotransmitters in different clinical types of obsessive-compulsive disorder

目的比较不同临床类型强迫症患者的临床特征及脑脊液、血浆中单胺类神经递质及其代谢产物的含量。方法将42例强迫症患者按照临床症状结合强迫量表评分分为不同临床类型，采用库仑阵列电化学高效液相色谱检测法测定不同临床类型强迫症患者脑脊液及血浆中5-羟色胺、去甲。肾上腺素、5-羟吲哚乙酸、高香草酸等物质的含量，并进行对比分析。结果强迫思维型和强迫行为型（简称单纯型）强迫症患者发病年龄较晚，病程较短，汉密顿焦虑量表评分高于混合型，而强迫量表评分低于混合型（P〈0．05）；混合型强迫症患者脑脊液中高香草酸含量显著高于强迫思维型和强迫行为型患者（P〈0．05）。结论不同类型的强迫症患者具有不同的临床特征，混合型强迫症患者脑脊液中高香草酸含量增高。

Objective To compare the clinical characteristics,CSF and plasma levels of monoamine neurotransmitters and their metabolites among different clinical types of obsessive-compulsive disorder （OCD）. Methods 42 OCD patients were divided into different clinical types according to clinical symptoms and sores of the Yale-Brown Obsessive-Compulsive Scale （Y-BOCS）,CSF and plasma levels of 5-HT, NE, 5- HIAA,HVA were determined using the Coulomb array electrochemistry high-performance liquid chromatography and contrastively analyzed among different clinical types of OCD patients. Results Age of onset in the patients with obsession and compulsion （briefly named simplex type） was later, course of diseases shorter, and their HAMA scores were higher and Y-BOCS lower than those of mixed type ones（P〈0.05）; CSF HVA levels were significantly higher in mixed type than obsession and compulsion patients （P〈0.05）. Conclusion Different types OCD patients have various clinical features, CSF levels of HVA of mixed type ones elevate.