尼莫地平对急性脑梗死患者血浆一氧化氮的影响

Effect of nimodipine on plasma nitric oxide level in acute cerebral infarction patients

目的：探讨尼莫地平对急性脑梗死患者血浆一氧化氮（NO）水平的影响。方法：83例急性脑梗死患者随机分为尼莫地平组42例和常规治疗组41倒，并以35名健康人作为正常对照纽。应用硝酸还原醇法测定治疗前后血浆NO水平。结果：尼莫地平纽扣常规治疗纽患者血隶NO水平明显高于正常对照组（P均〈0．05）；治疗后，两组患者血浆NO水平较治疗前均明显降低（P均〈0．05），尼莫地平组较常规治疗组血浆NO水平降低更明显（P均〈O．05）。结论：尼莫地平可以改善急性脑梗死患者的血管内皮功能，提示尼莫地平对急性脑梗死具有良好的治疗作用。

Objective：To investigate the effect of nimodipine on plasma nitric oxide （NO） level in acute cerebral infarction patients. Methods：Eight- y-three acute cerebral infarction patients were randomized into nimodipine therapy group（forty--two patients） and ordinary therapy group（forty-- one patients）. Thirty--five healthy people were set as control group. Plasma NO were measured by HNO3 deoxidize enzyme methods before and after the therapy. Results：Plasma NO levels were significantly higher both in nimodipine therapy group and ordinary therapy group than those in control group （all P（0.05） ;after the therapy,plasma NO levels were decreased significantly in nimodipine therapy group and ordinary therapy group （all P （0.05） ;plasma NO level in nimodipine therapy group was significantly lower than that in ordinary therapy group （P（0.05）. Conclasion： Nimodipine therapy could improve vessel endothelial function in acute cerebral infarction,moreover it could improve acute cerebral infarction prognosis.