摘要
目的:评价紫杉醇(Taxol)联合卡培他滨(Xeloda)治疗老年晚期胃癌的临床疗效和毒副反应。方法:对病理诊断的25例老年晚期胃癌患者,采用紫杉醇联合卡培他滨方案治疗:紫杉醇75mg/m2,静脉滴注3h,每周1次,连用2周;卡培他滨每日2500mg/m2,连用14天l以上化疗方案每3周重复,2个周期后评定疗效。结果:可评价疗效者21例,无完全缓解(CR),部分缓解(PR)10例(47.6%),稳定(SD)5例(23.8%),进展(PD)6例(28.6%),总有效率(CR+PR)为47.6%。中位进展期5~6个月,中位生存期8~9个月。主要毒副反应:骨髓抑制18例(85.7%),脱发15倒(71.4%),腹泻10例(47.6%),肌肉关节痛5例(23.8%)等。所有Ⅲ度毒副反应发生6例(28.5%),无治疗相关性死亡。结论:紫杉醇联合卡培他滨治疗老年晚期胃癌患者有效率较高,毒副反应可耐受,是老年晚期胃癌较理想的化疗方案。
Along with the effective form application like patient's choice, the contrast medium type and the dosage control, the correct hydration and stop using other kidneys toxically and so on, the contrast medium nephrosis (CIN) disease incidence rate drop gradually, but present CIN still was the medical source impatient kidney function failure (ARF) third cause of disease. This article summarizes as follows to the contrast medium nephro- sis dangerous factor.
出处
《按摩与康复医学》
2010年第3期74-75,共2页
Chinese Manipulation and Rehabilitation Medicine
关键词
胃肿瘤
紫杉醇
卡培他滨
药物治疗
The contrast medium Nephrosis Dangerous factor Research progress