微量泵输注3%盐酸氯普鲁卡因在硬膜外麻醉中的临床应用

Clinical value of 3% chlorprocaine hydrochloride for epidural anesthesia with micro-pump

[目的]观察比较3%盐酸氯普鲁卡因(可普诺)在硬膜外麻醉中分次给药和微量泵持续给药效果的区别。[方法]选择单纯硬膜外麻醉患者100例,随机分成两组,记录麻醉起效后病人的平均动脉压、阻滞范围变化和心率变化,以及肌松欠佳和镇痛欠佳的例数。[结果]微量泵持续给药方式与分次给药方式相比对病人的影响更小,麻醉效果更佳,差异有显著性意义:微量泵持续输注3%盐酸氯普鲁卡因组(微量泵组)的最大阻滞范围明显小于对照组,差异有显著性意义(P<0.01);术中平均动脉压下降幅度与对照组相比明显减少,差异有显著性意义(P<0.01);麻醉以后微量泵组)心率增加明显小于对照组,差异有显著性意义(P<0.01),肌松效果欠佳和辅助镇痛例数(微量泵组)组明显少于对照组(P<0.01)。[结论]应用微量泵持续性给药能够取得完善的麻醉效果,对病人干扰更小,更安全。

[Objective] To compare the efficacies of intermittent infusion and continuous infusion of 3% chlorprocaine hydrochloride with micro -pump in epidural anesthesia. [ Methods ] One hundred patients were randomly divided into two groups, the maximum block range, MAP, HR, The number of cases of muscle relaxant effects of poor and supporting analgesia were recorded. [ Results ] The effect of continuous infusion with micro - pump was better than intermittent infusion and significant differences in analgesia effects were observed. The maximum block range of micro - pump group was significantly less than that of the control group （ P 〈 0.01 ）. The MAP of micro - pump group decreased during the anesthesia was significantly less than that in the control group （P 〈 0.01 ）. The heart rate increased was significantly less than that in the control group （ P 〈 0.01 ）. The number of cases of muscle relaxant effects of poor and supporting analgesia was significantly less than that in the control group （P 〈 0.01 ）. [ Conclusion ] Continuous infusion of 3% chlorprocaine hydrochloride with micro - infusion pump in epidural anesthesia is perfect and safe.