抗细胞间粘附分子-1单抗对异丙肾上腺素所致心肌损害的保护作用

PROTECTIVE EFFECT OF ANTI ICAM 1 MAb ON ISOPROTERENOL INDUCED MYOCARDIAL DAMAGE IN RATS

为探讨抗细胞间粘附分子－１（ＩＣＡＭ－１）单抗对异丙肾上腺素（异丙肾）所致ＳＤ大鼠心肌损害的保护作用，在光镜下观察了经抗ＩＣＡＭ－１单抗预处理和未经预处理，均通过多次大剂量异丙肾导致的大鼠心肌损害（ＨＥ染色）的程度。结果：心肌损害程度处理组（多为Ⅱ级，５／６只）与对照组（多为Ⅲ级，６／７只）之间比较，差异有非常显著性意义（Ｐ＜０．０１）。另外还发现，处理组心肌损伤区的粒细胞聚集明显轻于对照组。提示抗ＩＣＡＭ－１单抗对异丙肾引起的心肌损害具有保护作用。

This study was to evaluate the effect of anti ICAM 1 MAb on isoproterenol induced myocardial damage. Repeated large dose isoproterenol induced myocardial damage (stained with hematoxylin and eosin) was examined under the microscope in SD rats with and without anti ICAM 1 MAb treatment. Significant differences in the degree of major myocardial damage were found between the treated group (grade Ⅱ,5/6) and the untreated group (grade Ⅲ,6/7)( P <0 01). In addition, accumulation of neutrophils was markedly reduced in the treated groups compared with the untreated groups as revealed in the tissue at the site of myocardial damage. This study suggests that the anti ICAM 1 MAb has significant protective effect against isoproterenol induced myocardial damage.