动态增强MRI基本原理及其在前列腺癌中的应用

Basic principles and clinical applications of dynamic contrast-enhanced MRI in prostate cancer

动态增强MRI可通过小分子钆对比剂无创地对组织血管特征进行评价,获得组织的血流灌注、微血管渗透性和细胞外的漏出间隙等参数。前列腺癌的血管生成是肿瘤的发生、进展、转移的重要因素之一。本文综述两种MR动态增强技术(T2*W和T1WDCE-MRI)的基本原理及其在前列腺癌的诊断和鉴别诊断、放疗方案的制定和治疗反应的评价及肿瘤复发的检出等方面的应用。

Dynamic contrast enhanced magnetic resonance imaging （DCE-MRI） enables non-invasive imaging characterization of tissue vascularity with small molecular weight gadolinium chelates. Depending on this technique, tissue blood perfusion, microvessel permeability and extraeellular leakage space can be obtained. The basic principles of two dynamic MRI techniques （T2^＊ W and T1W DCE MRI） and their applications in prostate cancer of DCE-MRI including diagnosis, differential diagnosis, formulation of treatment plan, evaluation of therapeutic reaction, detection of lesion recurrent were reviewed in this article.