内质网应激在酒精性肝病细胞凋亡中的作用

Contribution of endoplasmic reticulum stress to hepatocyte apoptosis in alcoholic liver disease

内质网应激是内质网生理功能发生紊乱的一种亚细胞器的病理状态,既是机体的一种自我保护机制,也是促进细胞凋亡的一条重要途径.在酒精性肝病中,可通过高同型半胱氨酸血症等的作用诱导内质网应激,并可导致肝细胞凋亡.本文就内质网应激在酒精性肝病细胞凋亡中的作用作一综述.

Endoplasmic reticulum stress represents a subcellular pathological state caused by a disorder of physiological function of the endoplasmic reticulum. Endoplasmic reticulum stress is not only a self-protective mechanism of the body, but also an important factor to promote cell apoptosis. In alcoholic liver disease, endoplasmic reticulum stress induced by several factors such as hyperhomocysteinemia can lead to hepatocyte apoptosis. In this article, we will review the contribution of endoplasmic reticulum stress to hepatocyte apoptosis in alcoholic liver disease.