血小板衍化内皮细胞生长因子在胰腺癌组织中的表达及其临床意义

Clinical significance of PD-ECGF expression in human pancreatic carcinoma

目的:观察血小板衍化内皮细胞生长因子(PD-ECGF)在胰腺癌组织中的表达,探讨其临床意义.方法:利用Elivison免疫组织化学法检测36例手术切除的胰腺癌及21例癌旁正常胰腺组织,以及胃癌、食管癌、肝癌、结肠癌、肺癌及乳腺癌组织各10例中PD-ECGF的表达.分析PD-ECGF与胰腺癌大小、分化程度及淋巴结转移的相关性.结果:PD-ECGF在胰腺癌组织中的表达阳性率显著高于在癌旁正常胰腺组织(88.9%vs28.6%,P<0.01).PD-ECGF在结肠癌、肝癌、乳腺癌、食管癌、胃癌及肺癌组织中的表达阳性率为60%、70%、80%、90%、90%及80%.Ⅱ-Ⅳ期胰腺癌组织中PD-ECGF的表达阳性率显著高于Ⅰ期胰腺癌组织(100%vs75%,P<0.05).结论:PD-ECGF为一种非特异性的肿瘤相关因子,其可能与胰腺癌的病程进展有关.

AIM：To investigate the expression of plateletderived endothelial cell growth factor （PDECGF） in human pancreatic carcinoma and evaluate its clinical significance.METHODS：Immunohistochemistry was used to detect the expression of PD-ECGF in 36 paraffinembedded pancreatic carcinoma specimens,21 tumor-adjacent normal tissue specimens,and 60 cancerous specimens derived from other tissues （stomach,colon,esophagus,liver,lung and breast;10 specimens each）.The expression of PD-ECGF in different tissues was compared.The correlation between PD-ECGF expression and clinical parameters in pancreatic carcinoma was analyzed.RESULTS：The positive rate of PD-ECGF in pancreatic carcinoma was higher than that in tumor-adjacent normal tissue （88.9% vs 28.6%,P 〈0.01）.The positive rates of PD-ECGF in cancerous colon,liver,breast,esophagus,stomach and lung tissues were 60%,70%,80%,90%,90% and 80%,respectively.The positive rate of PD-ECGF in pancreatic carcinoma at stage Ⅱ-Ⅳ was higher than that at stage Ⅰ （100% vs 75%,P〈 0.05）.CONCLUSION：PD-ECGF is an organ-unspecific tumor-associated protein that may be associated with the progression of pancreatic carcinoma.