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低浓度NO吸入对先天性心脏病伴肺动脉高压患儿血流动力学的影响

THE INFLUENCE OF LOW DOSE NITRIC OXIDE INHALATION ON THE HEMODYNAMICS IN PATIENTS WITH CONGENITAL HEART DISEASE COMPLICATED BY PULMONARY HYPERTENSION
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摘要 对4例先天性心脏病室间隔缺损伴肺动脉高压患儿用Swan-Ganz导管监测血流动力学的情况下,观察吸入10mg/LNO后肺动脉压力及心输出量等的改变,结果表明,先天性心脏病室间隔缺损合并肺动脉高压患儿吸入低浓度NO气后,平均肺动脉压及肺血管阻力均较基础状态明显降低(P<0.05),心输出量则较前增高。提示吸入10mg/LNO可明显降低先天性心脏病伴肺动脉高压患儿的肺动脉压力,增加心输出量。 The changes of pulmonary arterypressure and cardic output after inhalation of NitricOxide (NO) (10mg/L) in 4 patients with congenitalheart disease complicated by pulmonary hypertension were studied. The hemodynamic changes weremonitored via Swan-Ganz catheter. The resultsshowed that: in patients with congenital heart disease complicated by pulmonary hypertension, inbalation of NO caused decrease in pulmonary arterypressure (systolic, diastolic and mean ), pulmonaryvascular resistance (P < 0. 05) and increase incardic output (P <0. 05).
出处 《西安医科大学学报》 CSCD 1998年第4期569-571,共3页 Journal of Xi'an Medical University(Chinese)
关键词 NO 肺动脉高压 先天性心脏病 血流动力学 endothelial function nitric oxide pulmonary hypertension
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参考文献4

  • 1Bigatello LM ,Hurford WE,Kacmarek RM et al. Prolonged inhalation of low concentration of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation. Anestnzesiology,1994,80:761.
  • 2Pepke-Zaba J, Higenboltain JW, Dinth-Xuan AJ et al. Inhaled nitric oxide as a cause of selective pulmonary hypertension. Lancet, 1991, 338:1173.
  • 3Kinsclla JP,Ncish SP,Sheffer E et al. Low-dose inhalation nitric oxide in persistant pulmonary hypertension of the newborn. Lancet, 1992,340 : 819.
  • 4Moinard J,Manier G,Piliet O et al .Effect of inhaled nitric oxide on hemodynamics and Va/Q in equalities in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med,1994,149(6): 1482.

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