血清CEA和组织E—CD表达与胃癌转移关系的研究

THE RELATIONSHIP BETWEEN THE E-CD、CEAAND GASTRIC CANCER METASTASIS

采用免疫组化方法检测了31例进展期胃癌新鲜标本中E－CD蛋白表达以及患者术前血清中CEA水平，分析了它们与胃癌转移的关系。结果：胃癌标本中E－CD表达与胃癌分化程度、Borrmann分型、胃周淋巴结转移、腹膜播散有关；血清CEA阳性车与肿瘤体积大小、血行昨转移、腹膜播散有关。腹腔游离癌细胞与E－CD和血清CEA阳性年均有关。提示：E－CD低表达或缺失以及血清CEA升高与胃癌转移密切相关。

in order to analyse the relationshipbetween the E-CD、CEA and gastric cancer metastasis,we tested the E-CD protein expression in gastriccancer sample and serum CEA level in 31 cases ofadvanced gastric carcinomas with immunohistochemistry SABC and ELISA methods. It showedthat END protein expression related with the gastric cancer differentiation. Borrmann types. gastriclylnpha node metastasis and peritoneum dissemination while the PO8itive rate of serum CEA relatedwith the tumor volume.hepatic metastasis and peritoneum dissemination. Both of the E-CD and POstiverate of serum CEA related with the peritoneal exfoliated cancer cell. So we conclude that the reduced expression or short of E-CD and the rise of serumCEA promote the gastric carcinomas metastasis.Keyweeds gastric cancer; metastasis; E-CD; CEA; peritoneal exfoliated cancer cell