腹腔镜联合药物治疗子宫内膜异位症80例疗效观察

Observation on the clinical efficacy of 80 cases with endometriosis treated by laparoscopy combined with drug

目的:探讨腹腔镜联合药物治疗子宫内膜异位症的临床疗效。方法:采用腹腔镜联合药物的方法进行治疗。结果:在80例子宫内膜异位症患者中共失访4例,失访率5.00%(4/80)(其中孕三烯酮组失访1例,GnRH-α组失访2例,对照组失访1例)。在随访的26例孕三烯酮组子宫内膜异位症患者中有效15例,基本有效10例,无效1例,复发1例;25例Gn-RH-α组子宫内膜异位症患者中有效21例,基本有效3例,无效1例,复发1例;与对照组相比,腹腔镜与药物联合治疗的孕三烯酮组和GnRH-α组的有效率明显高于对照组(P<0.05);而GnRH-α组的有效率明显高于孕三烯酮组(P<0.05);结论:腹腔镜手术联合GnRH-α治疗子宫内膜异位症,可以降低疾病复发率,提高患者受孕率,是一种有效的临床治疗方法,值得临床推广使用。

Objective： To explore the clinical efficacy of laparoscopy combined with drug in treatment of endometriosis. Methods： Cases were treated by laparoscopy combined with drug. Results： The lost of follow up rate was 5.00% （4/80）, including 1 case in gestrinone group, 2 cases in GnRH -α group and 1 case in control group. In gestrinone group （26 cases followed up）, 15 cases, 10 cases, 1 case and 1 case were determined as effective, basic effective, ineffective and recurrence; while in GnRH -α group, the amounts were 21 cases, 3 cases, 1 case and 1 case, respectively ; the effective rates in gestrinone group and GnRH - α group were significantly higher than that in control group （ P 〈 0. 05 ） ; while the effective rate in GnRH - α group was significantly higher than that in gestrinone group （ P 〈 0. 05 ） . Conclusion： Combined application of laparoscopic surgery and GnRH-α can treat endometriosis, reduce the recurrence rate and increase the rate of conception, which is a effective method and should be popularized in county hospitals.