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苦参碱联合甘利欣注射液对慢性乙肝纤维化及血清TNF-α含量的影响

Effect of Sophocarpidine and Diammonium Glycyrrhizinate Injection on Hepatic Fibrosis and the Content of Tumor Necrosis Factor α of Chronicity Type B Hepatitis Patients
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摘要 目的:观察苦参碱联合甘利欣注射液对慢性乙肝纤维化及血清TNF-α含量的影响。方法:将135例慢性乙型肝炎患者随机分为两组,治疗组72例采用苦参碱联合甘利欣注射液治疗,对照组64例采用拉米夫定治疗,6个月后观察两组患者肝功能、乙肝病毒标志物、肝纤4项以及肿瘤坏死因子α(TNF-α)含量的变化,并判断疗效。结果:与治疗前相比,两组均能显著降低血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、透明质酸(HA)、Ⅲ型前胶原肽(PCⅢ)、层粘连蛋白(LN)、IV型胶原(IV-C)以及TNF-α含量,提高白蛋白/球蛋白比值(A/G)(P<0.01);在降低ALT、AST、HA、PCⅢ、IV-c以及TNF-α含量方面,治疗组明显优于对照组(P<0.05);对照组Hbv-DNA阴转率高于治疗组(P<0.05),治疗组HbeAg阴转率优于对照组(P<0.01);治疗组临床总有效率88.9%,对照组临床总有效率75.0%,两组比较具有统计学差异(P<0.05)。结论:苦参碱联合甘利欣注射液可降低血清TNF-α含量,抑制肝纤维化,同时还可抑制病毒复制,促进HBV复制标志物阴转,降低转氨酶,改善肝功能。 Objective:To observe the effect of sophocarpidine and diammonium glycyiThizinate injection on hepatic fibrosis and the content of tumor necrosis factor α(TNF -α) of chronicity type B hepatitis patients. Methods : 135 cases patients with chronicity type B hepatitis were devided into two groups at random; The treatment group ( n = 72) were treated by sophocarpidine and diammonium glycyrrhizinate injection,and control group(n =64) were treated by Lamivudine tablet,with one treatment period of 6 months; Liver function,type B hepatovirus marker,hepatic fibrosis index and TNF-ctwere measured after treatment, and the curative effect were judgement. Results: Compared with before treatment, the content of alanine aminotransferase (ALT), aspartate amino transferase (AST), hyalumnic acid (HA), precollagen Ill ( PC III) ,laminin(LN) ,collogen IV( IV - c) and TNF - α in blood plasma were increased,and the ratio of albumin and globulin(A/G) were decreased obviously in two groups (P 〈 0.01 ) ; compared with control group, the ALT, AST, HA, PC III, IV- c and TNF-α were different obviously in treatment groups( P 〈0.05 ). The rate of Hbv- DNA negative in control group surpass treatment group(P 〈 0.05 ) ; The rate of HbeAg negative in treatment group surpass control groups (P 〈 0. 01 ) ;The effective rate of treatment group was 88.9%, which was higher than that of control group (75.0%, P 〈 0. 05 ). Conclusion: sophocarpidine and diammonium glycyrrhizinate injection could decrease the content of TNF - ot and aminotransferase,restrain hepatic fibrosis and virus replication, improve the rate of Hbv - DNA negative and liver function.
作者 索海芬
出处 《中华中医药学刊》 CAS 2010年第2期446-448,共3页 Chinese Archives of Traditional Chinese Medicine
关键词 苦参碱注射液 甘利欣注射液 慢性乙型肝炎 肝纤维化 肿瘤坏死因子Α sophorcarpidine injection diammonium glycyrrhizinate injecfion chronicity type B hepatitis hepatic fi- brosis tumor necrosis factor α
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