异甘草素-多壁碳纳米管复合物的体外缓释行为

Sustained Release Behavior in Vitro of Complex of Isoliquiritigenin and Multi-walled Carbon Nanotubes

目的以异甘草素为模型药物,研究多壁碳纳米管(MWNTs)作为缓释载体的可行性。方法通过氧化处理MWNTs,改善其表面性质,利用SEM表征了氧化后的MWNTs(o-MWNTs)的表面形貌,借助全自动快速比表面积及孔隙度分析仪表征了MWNTs的比表面积和孔结构,并探讨o-MWNTs-异甘草素复合物在不同释放介质中的缓释行为。结果MWNTs经过氧化后制备得到的o-MWNTs-异甘草素复合物在2%十二烷基硫酸钠水溶液(2%SDS-水)和pH 6.8的2%十二烷基硫酸钠磷酸盐缓冲液(2%SDS-PBS)中缓释效果良好,分别达到42.03%和34.21%。o-MWNTs-异甘草素复合物在该2种溶出介质中的释放动力学基本符合H iguch i模型,释放良好。结论MWNTs可作为潜在缓释材料。

OBJECTIVE To investigate the possibility of multi-walled carbon nanotubes（MWNTs） as drug carrier to combine isoliquiritigenin and to explore the potential feasibility of MWNTs.METHODS Surface properties were improved by oxidization.Scanning electron microscope（SEM） and automated specific surface-area and pore-size analysis were used to characterize surface morphology,pore diameter and surface area of MWNTs,respectively.RESULTS The sustained release behavior of complex of isoliquiritigenin and oxidized multi-walled carbon nanotubes（o-MWNTs） was investigated in different dissolution medium.The sustained release effects of complex were excellent in 2%SDS-aqueous solution and 2%SDS-PBS solution,and the total release rates were 42.03% and 34.21%,respectively.And the release dynamics of o-MWNTs containing isoliquiritigenin were in accordance with the Higuchi model.CONCLUSION MWNTs could be used as drug carrier for sustained-release preparations.