摘要
目的观察βA4在帕金森病脑内的表达,探讨βA4表达与神经元变性、缺失的关系。方法用免疫组化的ABC法对脑组织切片进行βA4表达研究,同时做刚果红染色,观察βΑ4病理形态、阳性程度、脑内分布。结果βA4在皮质3、5层中有较强表达。而刚果红染色为阴性。结论βΑ4在脑组织中的表达并非Alzheimer病所特有,在PD病人中亦可见到。βA4免疫组化法的阳性结果不同于传统的刚果红染色法。βA4与神经元变性。
Objective To observe βA 4 expression in brain tissue in Parkinson disease and to investigate the effect of βA 4 expression on neuron degeneration and loss Methods By immunohistochemistry ABC method,we observed βA 4 plaque ,s the pathologic characteristics,level of expression and distribution in brains Simultaneously Congo red was employed to display βA 4 Results We found βA 4 expression in cortical layers 3 and 5 in PD,while using Congo red staining method,the result showed negative Conclusions The deposits of βA 4 in brain are not specific to Alzheimer ,s disease The result of immunohistochemistry staining is different from that of conventional Congo red method βA 4 is related to neuron degeneration and loss
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
1998年第6期339-341,共3页
Journal of Apoplexy and Nervous Diseases