新疆Kaposi肉瘤组织内EBV、HHV-8双重感染的调查

EBV、HHV-8 in tissue of Xinjiang Kaposi's sarcoma:an investigation of double infections

应用PCR方法，对20例新疆Kaposi肉瘤病理组织进行了EBV和HHV－8双重感染的调查。结果：20例Kaposi肉瘤病理组织中14例检出HHV－8DNA（70％），EBV均为阴性。正常皮肤对照：10例这两种疱疹类病毒均为阴性。作者认为新疆Kaposi肉瘤的发生与EBV的相关性很小，但明显与HHV－8感染有关，但是否HHV－8感染就是新疆Kaposi肉瘤发生的决定因素，仍需进一步研究。

Using the polymerase chain reaction (PCR), the authors searched for human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV) DNA sequences in lesions from patients with classic Kaposi's sarcoma (KS) in Xinjiang region. Of 20 tissue specimens from patients with KS, 14 (70 percent) were positive for HHV-8 DNA sequences but none was positive for EBV DNA. Both HHV-8 and EBV were negative in 10 cases of normal skin. The results suggest that EBV is not related to KS, but HHV-8 infection might play an important role in the pathogenesis of Xinjiang Kaposi's sarcoma.