学龄儿童VA、VC、VE摄入水平对免疫功能影响

Effect of vitamin A,C,E intake on immune function in school-age children

目的探讨膳食维生素A（VA）、维生素C（VC）、维生素E（VE）对儿童免疫功能的影响。方法选择河北省唐山市2所小学293名1-6年级学生进行一般情况、食物摄取频率和膳食调查,其中262名学生经家长知情同意后采静脉血测定免疫功能指标 营养计算器V1.6转换数据,SPSS 11.5统计软件进行分析。结果VA摄入水平为40%-20%推荐摄入量（RNI）时,CD4^＋、CD4^＋/CD8^＋、白介素-2（IL-2）、IgG及IgM分别为（27.83±12.38）%,1.23±0.12,（142.07±34.67）g/L,（10.49±0.47）,（1.73±0.02）g/L,与参考值比较,差异均有统计学意义（P〈0.01） VC摄入水平对CD3^＋、IgA及IgM有影响,当摄入水平分别低于100%和80%RNI时,CD3^＋、IgA低于参考值 低于60%RNI时,IgM高于参考值 当VE摄入水平低于120%、80%和80%适宜摄入量（AI）时,受其影响的CD4^＋、IL-2及IgG低于参考值。结论当VA摄入量≥120%RNI、VC摄入量≥120%RNI、VE摄入量≥160%AI时,对各免疫功能指标影响方能处于正常。

Objective To study effects of vitamin A,C,E intake on immune indicators in children with multi-variable analysis. Methods Totally 293 students from 1-6 grades were investigated about their general state of health, 5 days diet and 1 month food frequency and 262 children＇s immune indicators were determined with the consents of their parents. The intakes were transformed with nutrition calculator V1.6. The data were analyzed with SPSS 11.5 software. Results Vitamin A intake had effects on CD4 ^＋ , CD4 ^＋/CD8 ^＋ , IL-2, IgG and IgM. When vitamin A intakes were below 40 -20% of reference nutrient intake （ RNI）, the leves of IL-2, CD4 ^＋/CD8 ^＋, IgG and CD4 ^＋ were lower than normal levels. When vitamin A intake was below 100% of RNI,IgM was higher than normal level. Vitamin C intake had effects on CD3 ^＋ ,IgA and IgM. When vitamin C intakes were below 100% of RNI or 80% of RNI,CD3 ^＋ and IgA were less than normal. When vitamin C intake was below 60% of RNI,IgM was higher than that of normal levels. Vitamin E intake had effects on CD4^＋ ,IL-2 and IgG. When vitamin E intakes were below 120% of adequate intake（AI） or 80% of AI, the levels of immunity indicators were lower than normal level. Conclusion Children＇s immune levels are normal when their intakes of vitamin A ≥ 120% of RNI,vitamin C≥120% of RNI,and vitamin E≥160% of AI.