摘要
目的探讨HLA位点与移植物存活的关系。方法应用微量淋巴细胞毒试验方法对3例骨髓移植患者及其家庭成员(骨髓供者)共12例血液进行了HLA分型研究。结果1例患者两条HLA单倍型与其家庭成员供者相同,并移植成功;另一例患者的HLA型仅与其供者A、B两位点相同,DR位点可疑,最终移植失败;第3例患者HLA-A、B、DR位点与其供者无任何相同,未行移植。结论在骨髓移植中,供、受者双方HLA单倍型完全相同,特别是DR位点相同时,移植极易获得成功。
Objective To study the correlation between the HLA sites and the successful transplantation. Method HLA typing in 3 cases of bone marrow receivers and their family donators were studied by microcytotoxicity assay. Results\ Those two HLA haplotypes are identical with her donators had a successful transplantation, while the one whose HLA only identical in A,B sites with his donators had a unsuccessful transplantation. Conelusion\ The two identical HLA haplotypes including DR site between receiver and donator are very important in a successful bone marrow transplantation.
出处
《安徽医科大学学报》
CAS
1998年第6期429-430,共2页
Acta Universitatis Medicinalis Anhui
关键词
骨髓移植
HLA抗原
分型
bone marrow transplantation
HLA antigens
cytotoxicity tests, immunologic