儿童支气管哮喘家庭聚集性分析

Preliminary studies on family aggregation of child bronchial asthma

目的探讨儿童哮喘病有无家庭聚集现象，以便发现遗传因素在哮喘病病因中的作用。方法采用病例对照的研究方法，分别调查了１９６对哮喘病患儿和对照者的家系。结果病例组Ⅰ、Ⅱ级亲属哮喘病患病率明显高于对照组，病例组中有家庭史者为对照组２０倍，母患哮喘病其子女哮喘患病率明显高于父患哮喘病其子女哮喘患病率，对哮喘患者家庭用二项分布的数学模型拟合，其分布超出二项分布范围。

Objective To explore the role of family aggregation in attack of child bronchial asthma. Methods 392 pedigree (196 cases and 196 controls) have been investigated by a 1∶1 matched case control study. Results The results showed that prevalence of the first and the second degree relatives of the cases was significantly higher than that of the controls. The family hereditary history of the cases was 20 times higher than that of the controls. The prevalence of offspring of asthma mothers was significantly higher than that of those of asthma fathers. Conclusion Child bronchial asthma shows obvious family aggregation.