班布特罗对致敏豚鼠肺机械功能的影响

Effects of Bambuterol on Pulmonary Mechanical Function in Sensitized Guinea Pigs

目的：研究β2激动药班布特罗的支气管扩张作用。方法：通过测定致敏豚鼠抗原攻击前后的肺阻力（RL）和肺动态顺应性（Cdyn）变化，观察班布特罗对气道的扩张作用。结果：对照组的致敏豚鼠在抗原攻击后1min即达到反应高峰，RL比攻击前增高205．5％，在攻击后1～15min内（每3min测一次）比攻击前平均增高169．5±44．0％；Cdyn下降52．6％，平均下降50．0±4．2％。班布特罗2．0、5．0和10．0mg／kg组在攻击后1min时，RL值比攻击前分别增高80．6％、27．9％和15．0％，攻击后1～15min内（每3min测一次）比攻击前分别平均增高150．3±64．6％、47．7±18．9％和36．9±19．3％；Cdyn在攻击后1min时分别下降35．5％、16．3％和－1．3％，分别平均下降45．5±7．7％、18．6±4．6％和11．8±11．1％。经统计处理，班布特罗5．0和10．0mg／kg组与对照组比较，差异有显著性（分别为P＜0．05，P＜0．01）。结论：班布特罗（灌胃给药）对豚鼠有较强的气道扩张作用。

Objective:To study the bronchodilatation effect of β2-agonist bambuterol (Burn). Methods: The effects of drug on airway were evaluated by determining the changes of pulmonary resistance (RL) and pulmonarydynamic compliance (Cdyn). Results: Bronchial challenge of ovalbumin-sensitized guinea pigs induced 205. 5 % increase of RL and 52. 6% reduction of Cdyn with maximal response being observed in 1 min. Mean value of RL increase and of Cdyn reduction from 1 to 15 min (at intervals of 3 min) after antigen challenge was 169. 5±44. 0%and 50. 0±4. 2% respectively. Burn 2. 0,5. 0 and 10. 0 mg/kg ig induced maximal value of RL increase by80. 6%,27. 9 %, 15. 0%,Cdyn reduction by 35. 5 %, 16. 3 % and- 1. 3% in 1 min in sensitized guinea pigs,meanvalue of RL increase by 150. 3± 64. 6%, 47. 7 ± 18. 9 %, 36. 9±19. 3 % and Cdyn reduction by 45. 5± 7. 7 %, 18. 6± 4. 6%, 11. 8± 11. 1% from 1 to 15 min respectively. At 5. 0 and 10. 0 mg/kg ig given 2 h before ovalbuminaerosol, Barb almost completely inhibited the antigen-induced pulmonary function changes (P<0. 05 ～ 0. 01).Conclusion: Burn can significantly prevent bronchial challenge in sensitized guinea pigs.