摘要
目的探讨降钙素基因相关肽(CGRP)在正常妊娠时的变化及与妊高征发病的关系。方法采用放射免疫法对正常妊娠妇女59例(正常妊娠组)、妊高征孕妇57例(妊高征组)和正常非孕妇女10例(对照组)的血浆CGRP水平进行测定。结果正常妊娠组血浆CGRP水平随孕周的进展而增加,孕晚期达高峰(7684±2775ng/L);妊高征组其血浆CGRP水平随病情的加重而降低;中度妊高征患者CGRP水平(4976±2311ng/L)和重度妊高征患者CGRP水平(4635±2232ng/L)明显低于轻度妊高征患者(7128±2198ng/L)和正常晚孕妇女(7684±2775)(P<0.05)。血浆CGRP水平与平均动脉压、新生儿体重均无明显相关关系(P>0.05)。
Objective To study the change of calcitonin gene related peptide (CGRP) concentrations in maternal plasma of the normal pregnant women and patients with pregnancy induced hypertension (PIH) and relationship with CGRP and pathogenesis of PIH. Methods The plasma levels of CGRP in 59 cases of normal pregnant women (normal pregnancy group), 57 cases of PIH (PIH group), and 10 cases of nonpregnant women (control group) were determined with a sensitive radioimmunoassay. Results Plasma CGRP levels in normal pregnancy group increased with advance for the gestational week, reached the peak value (76.84±27.75 ng/L) in late trimester; plasma CGRP levels in PIH group decreased with series degree of PIH, levels of CGRP in moderate (49.76± 23.11 ng/L) and severe PIH (46.35±22.32 ng/L) were significantly lower than that in mild PIH (71.28± 21.98 ng/L) and the normal late pregnancy, the differences were significant ( P <0.005). There was no correlation between CGRP levels and the mean arterial pressure (MAP). Conclusions The change of CGRP may play an important role in the pathogenic mechanism of PIH.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1998年第12期715-716,共2页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠高血压
正常妊娠
CGRP
血浆降钙素基因
Calcitonin gene related peptide Pregnancy complications, cardiovascular Hypertension