正常妊娠和妊高征孕妇血浆降钙素基因相关肽的研究

The Changes of Plasma Calcitonin Gene related Peptide Level in Women with Normal Pregnancy and Pregnancy Induced Hypertension

目的探讨降钙素基因相关肽（ＣＧＲＰ）在正常妊娠时的变化及与妊高征发病的关系。方法采用放射免疫法对正常妊娠妇女５９例（正常妊娠组）、妊高征孕妇５７例（妊高征组）和正常非孕妇女１０例（对照组）的血浆ＣＧＲＰ水平进行测定。结果正常妊娠组血浆ＣＧＲＰ水平随孕周的进展而增加，孕晚期达高峰（７６８４±２７７５ｎｇ／Ｌ）；妊高征组其血浆ＣＧＲＰ水平随病情的加重而降低；中度妊高征患者ＣＧＲＰ水平（４９７６±２３１１ｎｇ／Ｌ）和重度妊高征患者ＣＧＲＰ水平（４６３５±２２３２ｎｇ／Ｌ）明显低于轻度妊高征患者（７１２８±２１９８ｎｇ／Ｌ）和正常晚孕妇女（７６８４±２７７５）（Ｐ＜０．０５）。血浆ＣＧＲＰ水平与平均动脉压、新生儿体重均无明显相关关系（Ｐ＞０．０５）。

Objective To study the change of calcitonin gene related peptide (CGRP) concentrations in maternal plasma of the normal pregnant women and patients with pregnancy induced hypertension (PIH) and relationship with CGRP and pathogenesis of PIH. Methods The plasma levels of CGRP in 59 cases of normal pregnant women (normal pregnancy group), 57 cases of PIH (PIH group), and 10 cases of nonpregnant women (control group) were determined with a sensitive radioimmunoassay. Results Plasma CGRP levels in normal pregnancy group increased with advance for the gestational week, reached the peak value (76.84±27.75 ng/L) in late trimester; plasma CGRP levels in PIH group decreased with series degree of PIH, levels of CGRP in moderate (49.76± 23.11 ng/L) and severe PIH (46.35±22.32 ng/L) were significantly lower than that in mild PIH (71.28± 21.98 ng/L) and the normal late pregnancy, the differences were significant ( P <0.005). There was no correlation between CGRP levels and the mean arterial pressure (MAP). Conclusions The change of CGRP may play an important role in the pathogenic mechanism of PIH.