烧伤早期核黄素不同补充方式对其尿中含量的影响

Influence of different routes of riboflavin administration on its level in urine at an early stage of burns

目的旨在调查口服核黄素在烧伤早期急救阶段使用的可行性和有效性。方法通过对烧伤大鼠及患者的尿样收集，采用核黄素荧光测定法动态观察了胃饲、腹腔注射、口服、静脉滴注等不同补充途径的尿内核黄素含量的变化情况。结果（1）烧伤后早期机体内核黄素显著下降；（2）同一剂量的核黄素，无论是静脉、腹腔注射还是口服、胃饲，补入后约20min尿中含量无明显差异。结论烧伤早期适量补充核黄素是必要的，作为简便、经济、安全的补充途径，口服还具备快速、有效的功能。

This experiment was aimed at investigating the feasibility and effectiveness of oral administration of riboflavin at an early stage of severe burns. The levels of riboflavin in urine sample collected from burned rats and patients was determined by fluorospectrophotometry and the variations in the levels by different routes of riboflavin supplement namely gastric feeding (GF), intraperitoneal injection (IP), oral administration (OA), intravenous injection (IV), were compared. The results showed that there was a phase of riboflavin deficiency in the early stage of burns and the same dosage of riboflavin had no significant differences in the levels of riboflavin in urine between GF,IP,OA and IV 20 min after administration. The results suggest that it is necessary to administer riboflavin for burn patients at an early stage of burn and its oral administration is effective, rapid, safe and economical.