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再生基因家族在消化道肿瘤中的研究进展 被引量:1

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摘要 再生基因(regenerating gene,Reg)自1988年由Terazono等在老鼠再生胰岛β细胞中首次发现后,其家族成员陆续被发现表达于人类多种组织中,其在糖尿病、炎症、创伤和肿瘤尤其是消化道肿瘤中的作用越来越受到重视。近年来国内外学者研究发现Reg基因及其蛋白表达与恶性肿瘤尤其是消化道肿瘤的发生发展、生物学行为和预后有密切的关系。现就Reg基因及其蛋白表达等方面的国内外研究进展加以综述。
作者 张宁 肖菊香
出处 《癌症进展》 2010年第1期67-70,共4页 Oncology Progress
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  • 1陈柳青,曾学思,孙建方.石蜡包埋皮肤组织标本中提取RNA进行逆转录PCR的研究[J].中国麻风皮肤病杂志,2006,22(1):20-22. 被引量:3
  • 2景红梅,克晓燕,董菲,高子芬,周晓鸽.石蜡包埋组织提取RNA检测API2-MALT1融合基因的研究[J].北京医学,2006,28(3):129-131. 被引量:7
  • 3Taiichi W, Hiroshi Y, Kazuo T, Hiroshi Y & Hiroshi O, Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem, 1990, 265: 7432-7439.
  • 4Hirokazu F, Fujii S, Takeda J. Kayhara T, Sekikawa A, Nanakin A, Suzuki K, Hisatsune H, Seno H,Sawada M, Fujimor T & Chiba T, Expression of Reg Ia protein in human gastric cancers. Digestion, 2004, 69 (3): 177-184.
  • 5Dipok, KD, Udagawa J, Ishihara S, Otani H, Kinoshita Y, Takasawa S, Okamoto H, Kubota H, Fujii T, Tachibana M & Nagasue N, Expression of regenerating gene Ⅰ in gastric adenocarcinomas. Cancer, 2004, 100 (6): 1 130-1 136.
  • 6Hocine R, Guiseppe M, Gustavo VM, Sophne V, Loienzo M, Philippe S, Jean-Charles D, & Juan-L I, pap, reg Iα and reg Iβ mRNAs are concomitantly up-regulated during human colorectal carcinogenesis. Int J Cancer, 1999, 81: 688-694.
  • 7Harada, K, Zen Y, Kanemori Y, Chen T CH, Chen MF, Yeh TS, Jan YY, Masuda S, Nimura Y, Takasawa S, Okamoto H & Nakanuma Y, Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions. Hepatology, 2001, 33 (5): 1 036-1042.
  • 8Kimura N, Hiroshi Y, Hiroshi 0 & Hiroshi N, Expression of human regenerating gene mRNA and its product in normal and neoplastic human pancreas. Cancer, 1992, 70:1 857-1863.
  • 9Akira, S, Fukui H, Fujii S, Nanakin A, Kanda N, Uenoyama Y, Sawabu T, Hisatsune H, Kusaka T, Ueno S, Nakase H, Seno H, Fujimori T & Chiba T, Possible role of REG Ia protein in ulcerative colitis and colitic cancer. Gut, 2005, 54:1 437-1444.
  • 10Okamoto H. & Shin T, The CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg) -Reg receptor system in β-cells. Diabetes, 2002, 51 (Suppl. 3): S 462-S 473.

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  • 1Nagashima F,Ohtsu A,Yoshida S,et al.Japanese nationwide post-marketing survey of S-1 in patients with advanced gastric cancer[J].Gastric Cancer,2005,8(1):6-11.
  • 2Koizumi W,Narahara H,Hara T,et al.S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer(SPIRITS trial):a phase III trial[J].Lancet Oncol,2008,9(3):215-221.
  • 3Jin M,Lu H,Li J,et al.Randomized 3-armed phase III study of S-1 monotherapy versus S-1/CDDP(SP)versus 5-FU/CD-DP(FP)in patients(pts)with advanced gastric cancer(AGC):SC-101 study[J].J Clin Oncol,2008,26(15s):4533.
  • 4Longley DB,Harkin DP,Johnston PG.5-fluorouracil:mechanisms of action and clinical strategies[J].Nat Rev Cancer,2003,3(5):330-338.
  • 5Tsuruo T,Naito M,Tomida A,et al.Molecular targeting therapy of cancer:drug resistance,apoptosis and survival signal[J].Cancer Sci,2003,94(1):15-21.
  • 6Matsubara J,Nishina T,Yamada Y,et al.Impacts of excision repair cross-complementing gene 1(ERCC1),dihydropyrimidine dehydrogenase,and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer[J].Br J Cancer,2008,98(4):832-839.
  • 7Sekikawa A,Fukui H,Fujii S,et al.REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer[J].Gastroenterology,2005,128(3):642-653.
  • 8Sekikawa A,Fukui H,Fujii S,et al.REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells[J].Carcinogenesis,2008,29(1):76-83.
  • 9罗菁,罗珉,王小禾.晚期胃癌化疗115例分析[J].中国实用内科杂志,2010,30(S1):39-40. 被引量:9
  • 10刘晓光,杨月琴,李继承.原发性胃癌REG Iα基因表达与临床病理特性的关系[J].解剖学报,2009,40(4):614-620. 被引量:1

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