外阴白色病变患者病变区血管的免疫组化观察

Immunohistochemical observation on blood vessels in lesion area in patients with white lesions of vulva

目的:观察外阴白色病变患者局部组织的血管情况,探讨外阴白色病变的发病机理。方法:以60例外阴白色病变患者为观察组,20例其他外阴手术者的外阴皮肤为对照组,采用免疫组化SP法,观察CD34在外阴白色病变皮肤中的表达及MVD值,并与对照组进行对照。结果:CD34在三型外阴白色病变中均有表达,其阳性率与对照组比较差异均有统计学意义(P<0.01),三型之间的阳性率比较差异亦有统计学意义(P<0.01)。外阴白色病变的MVD值与对照组比较差异均有统计学意义(P<0.01),三型白色病变的MVD值比较差异亦有统计学意义(P<0.01)。结论:外阴白色病变存在血管的异常,血管的改变可能是造成营养不良的直接原因。

Objective： To observe the regional vascular status of white lesions of vulva, explore the pathogenesis of white lesions of vulva. Methods： 60 cases with white lesions of vulva were selected as observation group, while 20 cases without white lesions of vulva were selected as control group, then immunohistochemical SP method was used to detect the expression level of CD34 and the value of MVD in regional skin of white lesions of vulva, the results were compared to those in control group. Results： CD34 expressed in three types of white lesions of vulva. There was significant difference in positive rate of CD34 and MVD value between observation group and control group （ P 〈 0. 01 ）, and there was significant difference among the three types of white lesions of vulva （P 〈 0. 01 ） . Conclusion： Abnormal blood vessels can be found in white lesions of vulva, which maybe the direct cause of malnutrition.