摘要
利用手性源(2R,3S)-3,4-二甲基-2-苯基-1,4-氧氮杂-5,7-二酮(1)合成了具有光学活性的7,8-二甲基-3,6-二苯基-5-氧-8-氮螺[2.6]壬-4,9-二酮(3).测定了化合物(3)的晶体结构,并讨论了在环加成反应中的不对称诱导作用的机理.
Band on the synthesis of chiral compound (2R, 3S)-3, 4-dimethy1-2-phenyl -1, 4-oxazepine-5, 7-dione, 7, 8-dimethyl-3, 6-diphenyl-5-oxa-8-aza-spiro[2.6] nonane-4, 9-dione was synthesized in high optical purity. X ray single-crystal diffraction confirmed the crystal structure of this spiro-compound. The Crystal is orthorhombic, space group P212121 (#19) with Crystal parameters of a=1.049 6 (3) mm, b=2.862 6(3)mm, c=0.5938 (4) nm V=1.779(1)nm3, Z=4,Pc=1.252g·cm-3, 0.037. The X ray structure of compound (3) shoal the 1, 4-oxazepine-5, 7-dione ring displays a pseudoboat conformation in the Crystal.
出处
《北京师范大学学报(自然科学版)》
CAS
CSCD
北大核心
1998年第4期515-519,共5页
Journal of Beijing Normal University(Natural Science)
基金
国家自然科学基金!29372038
关键词
不对称合成
晶体结构
螺环化合物
氧氮杂草二酮
1
4-oxazepine-5
7-dione
asymmetric synthesis
crystal structure
spiro-compound