正交试验优选牙周康胶囊的水提醇沉工艺

Optimization of Extraction Process of Yazhoukang Capsule by Orthogonal Experiment

目的研究牙周康胶囊的水提醇沉工艺,优选最佳工艺。方法采用正交试验法,以干膏率和芍药苷含量为检测指标,考察4种因素(煎煮次数、加水量、煎煮时间、醇沉浓度)对工艺的影响。结果牙周康胶囊的最佳水提醇沉工艺为:加16倍水,每次煎煮1h,煎煮3次,醇沉浓度为40%。结论确定的提取方法适合于牙周康胶囊的制备。

Objective To optimize the preparing procedures of water extraction and alcohol precipitation of Yazhoukang Capsule. Methods The ratio of dry extraction and the content of paeoniflorin were used as indexes, orthogonal test was used for studying the influence on the process of four factors including decocting times, amount of water, decocting times, precipitating concentration of alcohol. Results The optimized preparation conditions were added 16 times water, decocting for 3 times, 1 h for each time and alcohol concentration of 40%. Conclusion The established method is suitable for extracting Yazhoukang Capsules preparation.