摘要
RTN3是RTN家族的成员之一,因其主要定位于内质网,所以用reticulon来命名.RTN3与RTN4B是RTN家族中目前已知的、唯一一对具有凋亡诱发功能的基因.过表达的RTN3介导了真核细胞的三大凋亡信号转导通路:死亡受体途径、线粒体途径、内质网途径,并使之交联形成凋亡调控网络;RTN3可与RTN4B相互作用,形成同源或异源二聚来调控细胞凋亡.另外,过表达RTN3还参与了细菌的类凋亡作用.RTN3广泛表达于多种组织,其过表达诱发凋亡的机制的总结将让人们更好的了解RTN3及其家族,完善细胞凋亡的信号转导研究.
RTN3, a protein located in endoplasmic reticulum which could induce cell apoptosis, is a member of RTN family. RTN3 and RTN4B are known as the only pair having apoptosis-inducing function in RTN family in present. Over-expressed RTN3 takes part in death receptor-mediated pathway, mitochondrial pathway, endoplasmic reticulum pathway, and regulates the network of these three pathways. The apoptosis-inducing activity of RTN3 and RTN4B in normal cell line is regulated by their homodimerization or heterodimerization. At the same time, RTN3 induced cell death of bacteria. For the widespread expression of RTN3, the current state of knowledge about RTN3 and its mechanism on apoptosis are introduced. The study on RTN3 and its family will be beneficial to the understanding on the cell signal transduction of apoptosis.
出处
《生命科学研究》
CAS
CSCD
2010年第1期80-84,共5页
Life Science Research
基金
国家自然科学基金资助项目(30800476)
教育部博士点基金新教师项目(422201027)
关键词
RTN3
凋亡
信号转导
RTN3
apoptosis
cell signal transduction
