突触后致密区与突触可塑性

Postsynaptic Dense Area and Synaptic Plasticity

突触是神经元之间的连接部位,生物信号从突触前膜经突触传递到突触后膜。突触的数量和功能发生改变可引起突触可塑性的改变,进而影响学习记忆能力。突触后致密区与突触可塑性的关系十分密切,对于维持突触发挥正常功能至关重要。本文从突触后致密区的发现和组成成分、参与突触可塑性的主要神经递质、以及突触后致密区与突触可塑性的关系等3方面研究进展做一简要综述。

Synapses are connections between neurons, biological signals are transferred from the presynaptic membrane by the synaptic transmission to the postsynaptic membrane. Changes in the number and function of synapsis can cause changes in synaptic plasticity, thereby can affect learning and memory. Postsynaptic dense area and the close relationship between synaptic plasticity are essential for the maintenance of synaptic function properly. In this article, we make a brief overview on the research of postsynaptic dense area including its discovery and composition, participation in a major neurotransmitter in synaptic plasticity, as well as the relationship between postsynaptic dense area and the synaptic plasticity.