不稳定心绞痛患者高敏C-反应蛋白与冠状动脉病变程度的关系

Relationship between High-sensitivity C-reactive Protein and Severity of Coronary Artery Lesions in Unstable Angina Patients

目的探讨高敏C-反应蛋白(high-sensitive C-reactive protein,CRP)与不稳定心绞痛患者冠状动脉病变程度的关系及其临床意义。方法选择首都医科大学宣武医院心脏科不稳定心绞痛患者共1 528例(男954例,女574例)。抽取每位患者的空腹静脉血并测定高敏C-反应蛋白(CRP)水平。所有入选患者均行冠状动脉造影,对造影结果用Gensini积分法评价其冠状动脉狭窄的程度,并分为轻度、中度和重度狭窄3组。用SPSS 10.0统计软件分析冠状动脉狭窄程度不同患者高敏C-反应蛋白水平的差异。结果随着冠状动脉狭窄程度的加重,患者的高敏C-反应蛋白水平明显升高。结论血高敏C-反应蛋白水平可作为冠状动脉病变严重程度的预测因子。

Objective To observe the relationship between high-sensitivity C-reactive protein and severity of coronary artery lesions in unstable angina patients. Methods Totally 1 528 patients（954 males and 574 females） with unstable angina pectoris seen in our hospital were enrolled into this study. High-sensitivity C-reactive protein（CRP） levels were measured in all patients. Coronary angiography was performed in every patient, and the severity of coronary stenosis was evaluated by using the Gensini scoring system. The patients were divided into three groups which were mild, moderate and severe, according to the Gensini score. The data were analyzed by SPSS software. We studied the relationship between high-sensitivity C-reactive protein and severity of coronary artery lesions in unstable angina patients.Results The CRP levels were significantly correlated with the severity of coronary stenosis（P〈0.01）. Conclusion The high-sensitivity CRP levels might be an important risk factor related with the severity of coronary stenosis.