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程序性死亡-1及其配体信号通路在移植免疫中的作用 被引量：1

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摘要 程序性死亡-1（PD-1）为负性调控共刺激分子，系T淋巴细胞和B淋巴细胞表面受体，属于免疫球蛋白超家族Ⅰ型跨膜糖蛋白，在T、B淋巴细胞抗原受体激发后呈诱导性表达。PD-1与其2个配体PD-L1和PD-L2结合，在免疫应答中起着负性调控作用。目前，人们愈加关注PD-1／PD-L信号通路与临床疾病的关系，如移植后排斥反应、哮喘、1型糖尿病等。本文对PD-1／PD-L信号通路在移植免疫中的作用进行如下综述。
作者 王雅文 王振 石炳毅
机构地区 解放军第三
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2010年第1期57-59,共3页 Chinese Journal of Organ Transplantation
关键词 程序性死亡 信号通路 移植免疫 配体 免疫球蛋白超家族 淋巴细胞抗原受体 PD-L2 T淋巴细胞
分类号 R392 [医药卫生—免疫学]
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参考文献25

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二级参考文献10

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中华器官移植杂志
2010年 第1期

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