自体复合富血小板凝胶在胫骨非感染性不愈合中的初步应用

Application of autologous platelet-rich glue combined with particulate of cancellous bone in the treatment of aseptic tibial nonunion

[目的]探讨自体复合富血小板凝胶治疗胫骨非感染性不愈合的临床可行性。[方法]选择60例胫骨干中下1／3骨小连患者随机分为试验组和对照组（各30例），试验组植入富血小板凝胶复合白体松质骨颗粒，对照组仅植入自体松质骨颗粒。本次手术距受伤时间平均10．5个月（7—36个月），平均38岁，术后观察全身和局部反应及连续X线表现，随访平均22个月（12～36个月），按Johner—Wruh评分评价最终结果进行统计学分析。[结果]两组在8个月内均骨性愈合，试验组和对照组之间有统计学差异。[结论]富血小板凝胶具有促进骨折愈合的生物活性，自体复合PRG是较理想的骨移植材料。

[ Objective] To probe the probability of autologous platelet-rich glue （PRG） combined with particulate of cancel- lous bone in treating the aseptic tibial nonunion. [ Method] Sixty patients with tibial nonunion in distal 1/3 fragment were randomly divided into 2 groups. Each group had thirty patients. PRG combined with particulate of autogenous cancelhms bone was transplanted in the experimental group while paniculate of cancellous bone was applied in the control group. The mean time to the operation was 10.5 months （7 -36 months） and the average age were 38 years old. The postoperative systemic and local reaction,and X-ray linings of tibial nonunion were observed. The average follow-up was 22 months. According to the Johner-Wruh scoring system the results were statistically analyzed. [ Result] At 8 months bony union was all achieved. There was a remarkable difference between those of experimental and control groups. [ Conclusion] PRG had an important role in speeding bone healing, and the combination of PRG and paniculate of autogenous cancellous bone is an ideal alternative of bone transplantation.