肿瘤细胞能量代谢机理的研究进展

Advance in Bioenergetic Metabolic Mechanisms of Cancer Cell

目的总结恶性肿瘤细胞能量代谢的研究进展。方法复习相关资料,就近年来恶性肿瘤细胞能量代谢的研究进展进行综述。结果恶性肿瘤具有独特的能量代谢特点,缺氧的肿瘤细胞生长和增殖需要稳定的能量来维持代谢。糖的摄取和糖酵解处于增高状态是其生物学特征,葡萄糖转运和代谢对肿瘤细胞至关重要,且导致不良的预后。结论研究缺氧诱导相关基因与肿瘤的关系将有助于破解能量代谢的机理,为肿瘤的诊断和治疗提供有力的证据及新的思路和途径,改善既往的治疗策略,给肿瘤患者更合理和个性化的治疗。

Objective To summarize the advance of bioenergetic metabolic mechanisms of cancer cell.Methods Literatures about the recent studies on the bioenergetic metabolic mechanisms of cancer cell were reviewed.Results Cancer cells required a steady source of metabolic energy in order to continue their uncontrolled growth and proliferation.Accelerated uptake of glucose and glycolysis was one of the biochemical characteristics of hypoxia cancer cells.Glucose transport and metabolism were essential for the survival of tumor cells,leading to poor prognosis.Conclusions The studies on relationships between hypoxia-inducible genes and cancer have come a new understanding of the bioenergetic metabolic mechanisms of cancer cell,become new and important supplementary means of diagnosis and treatment of cancer,and enhanced existing strategies so that the treatment could be more rationally applied and personalized for cancer patients.