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磷酸化ATF2、STAT3在隆突性皮肤纤维肉瘤和皮肤纤维瘤中的表达 被引量：2

Expression of phosphorylated - ATF2 and phosphorylated - STAT 3 in dermatofibrosarcoma protuberans and dermatofibroma
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摘要 目的:检测磷酸化活化转录因子2(p-ATF2)和磷酸化细胞信号传导与转录活化因子3(p-STAT3)在隆突性皮肤纤维肉瘤(DFSP)和皮肤纤维瘤(DF)中的表达。方法:采用免疫组化ABC法检测p-ATF2和p-STAT3分别在15例DFSP和18例DF皮损石蜡包埋切片中的表达。结果:在15例DFSP中,分别有13例和14例高表达p-ATF2和p-STAT3。而在18例DF中,分别有8例和6例表达p-ATF2和p-STAT3。DFSP中p-ATF2和p-STAT3的表达均显著高于DF中的表达(P<0.05)。在DFSP中,pATF2与p-STAT3阳性表达呈高度相关性(r=0.63,P<0.05)。结论:p-ATF2和p-STAT3在DFSP中呈高表达,提示它们在DFSP的发生和发展中可能起一定作用。 Objective： Investigate the expression of phosphorylated ATF2 （p- ATF2 ） and phosphorylated STAT 3 （p - SrAT 3） protein in DFSP and dermatofibroma and assess the relationships between them. Methods： 15 paraffin embedded DFSP specimens and 18 paraffin embedded dermatofibroma specimens were subjected to immunohistochemical staining for p- ATF2 and p- STAT3. Results： P- ATF2 was expressed in 13 out of 15 DFSP, and p - STAT3 was expressed in 14 out of 15 DFSP specimens. However, p- ATF2 was expressed in 8 out of 18 dermatofibroma specimens, and p - STAT3 was expressed in 6 out of 18 dermatofibroma specimens. The expressions of p - ATF2 and p - STAT3 in DFSP were significantly higher than those in dermatofibroma respectively （P 〈 0.05）. There was significant correlations between p - ATF2 and p - STAT3 expression （ r = 0.63, P 〈 0.05） in DFSP. Condusion： This study suggests that the overexpression of p - ATF2 and p - STAT 3 may play a pivotal role in the oncogenesis of DFSP.
作者 陈思远 钱悦 吴艳 朱里 黄长征 涂亚庭
机构地区 华中科技大学同济医学院附属协和医院皮肤科
出处 《中国麻风皮肤病杂志》 2010年第1期11-13,共3页 China Journal of Leprosy and Skin Diseases
关键词 磷酸化活化转录因子2 磷酸化细胞信号传导与转录活化因子3 隆突性皮肤纤维肉瘤 activating transcription factor- 2 signal transducer and activator of transcription - 3 dermatofibrosareoma protuberans
分类号 R739.5 [医药卫生—肿瘤] R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献14

  • 1Pedeutour F, Simon MP, Minoletti F, et al. Translocation t(17;22) (q22; q13) in dermatofibrosarcoma protuberans. A new tumor- associated chromosome rearrangement. Cytogenet Cell Genet 1996;72:171 - 174.
  • 2Lewis JS, Vijayanathan V, Thomas TJ, et al. Activation of cyclin D1 by estradiol and spermine in MCF- 7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF - 2. Oncol Res 2005;15:113 - 128.
  • 3Niu G, Bowman T, Huang M, et al. Roles of activated Src and STAT3 signaling in melanoma tumor cell growth. Oncogene 2002;21: 7001 - 7010.
  • 4Chen SY, Takeuchi S, Moroi Y, et al. Concordant overexpression of phosphorylated ATF2 and STAT3 in extramammary Paget's disease. J Cutan Pathol 2009; 36:402 - 408.
  • 5Recio JA, Merlino G. Hepatocyte growth factor/scatter factor induces feedback up- regulation of CD44v6 in melanoma cells through Egr-I. Cancer Res 2003;63:1576- 1582.
  • 6Papassava P, Gorgoulis VG, Papaevangeliou D, et al. Overexpression of activating transcription factor - 2 is required for tumor growth and progression in mouse skin tumors. Cancer Res 2004;64:8573 - 8584.
  • 7Bhoumik A, Ivanov V, Ronai Z. Activating transcription factor 2 - derived peptides alter resistance of human tumor cell lines to tdtraviolet irradiation and chemical treatment. Clin Cancer Res 2001;7:331 -342.
  • 8Bhoumik A, Huang TG, Ivanov V, et al. An ATF2 - derived peptide sensitizes melanomas to apoptesis and inhibits their growth and metastasis. J Clin Invest 2(302; 110: 643 - 650.
  • 9马向涛,王杉,叶颖江,社如昱,崔志荣.Stat3及其靶基因产物与结直肠癌恶性程度关系的研究[J].癌症,2003,22(11):1135-1139. 被引量：31
  • 10Masuda M, Suzui M, Yasumatu R, et al. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 2002;62:3351 - 3355.

二级参考文献22

  • 1Bowman T, Garcia R, Turkson J, et al. STATs in oncogeoesis [J]. Oncogene, 2000, 19(21): 2474 - 2488.
  • 2Levy DE, Damell JE Jr. Stats: transcriptional control and biological impact[J]. Nat Rev Mol Cell Biol, 2002, 3(9):651 - 662.
  • 3Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells[J]. Immunity, 1999,10(1): 105-115.
  • 4Grandis JR, Drenning SD, Zeng Q, et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo[J]. Proc Natl Acad Sci U S A, 2000, 97 (8) : 4227 - 4232.
  • 5Real PJ, Sierra A, De Juan A, et al. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells[J]. Oncogene, 2002, 21 (50):7611 -7615.
  • 6Dhir R, Ni Z, Lou W, et al. Stat3 activation in prostatic carcinomas[J]. Prostate, 2002, 51 (4): 241 - 246.
  • 7Wang S, Evers BM. Caco-2 cell differentiation is associated with a decrease in Stat protein levels and binding[J]. J Gastrointest Surg, 1999, 3(2): 200 -207.
  • 8Masuda M, Suzui M, Yasumatu R, et al. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D 1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma[J]. Cancer Res, 2002, 62(12): 3351-3355.
  • 9Bromberg JF, Wrzeszczynska MH, Devgan G, et al. Stat3 as an oncogene[J]. Cell, 1999, 98(3): 295 - 303.
  • 10Huang M, Page C, Reynolds RK, et al. Constitutive activation of stat3 oncogene product in human ovarian carcinoma cells[J]. Gynecol Oncol, 2000, 79 ( 1 ) : 67 - 73.

共引文献42

同被引文献24

  • 1Pedeutour F,simon MP,Minoletti F,et al.Translocation t(17;22)(q22;q13)in dermatofibrosarcoma protuberans:A new tumor ssociated chromosome rearrangement.Cytogenet Cell Genet 1996;72(2-3):171-174.
  • 2Lin N,Urabe K,Moroi Y,et al.Overexpression of phosphorylated -STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans.Eur J Dermatol 2006;16(3):262-265.
  • 3Botchkarev VA,Yaar M,Peters EM,et al.Neurotrophins in skin biology and pathology.J Invest Dermatol 2006;126(8):1719-1727.
  • 4Truzzi F,Marconi A,Lotti R,et al.Neurotrophins and their receptors stimulate melanoma cell proliferation and migration.J Invest Dermatol 2008;128(8):2031-2040.
  • 5Geldof AA,Van Haarst EP,Newling DW.Neurotrophic factors in prostate and prostatic cancer.Prostate Cancer Prostatic Dis 1998;1(5):236-241.
  • 6Yang ZF,Ho DW,Lam CT,et al.Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinoma.Cancer Res 2005;65(1):219-225.
  • 7Lai PC,Chiu TH,Huang YT,et al.Overexpression of BDNF and TrkB in human bladder cancer specimens.Oncol Rep 2010;24(5):1265-1270.
  • 8Qian Y,Takeuchi S,Chen SJ,et al.Nerve growth factor,brainderived neurotrophic factor and their high-affinity receptors are overexpressed in extramammary Paget's disease.J Cutan Pathol 2010;37(11):1150-1154.
  • 9Zhang S,Guo D,Luo W,et al.TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells.BMC Cancer 2010;10:43.
  • 10Au CW,Siu MK,Liao X,et al.Tyrosine kinase B receptor and BDNF expression in ovarian cancers-Effect on cell migration,angiogenesis and clinical outcome.Cancer Lett 2009;281(2):151-161.

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中国麻风皮肤病杂志
2010年 第1期

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