毛乳头细胞与雄激素性秃发的关系

Relation between dermal papilla cells and androgenetic alopecia

雄激素性秃发是最常见的脱发类型，目前已知是多基因遗传性疾病，与雄激素尤其是二氢睾酮水平及精神因素有关，具体发病机制不明确。毛乳头细胞来源于成纤维细胞，是构成毛乳头的间充质细胞。可表达雄激素受体和分泌多种细胞因子，诱导毛囊再生，在调控毛囊的周期性生长中起重要作用。且毛乳头细胞参与雄激素的代谢，雄激素通过诱导易感毛囊毛乳头细胞分泌细胞因子引起脱发。可见毛乳头细胞与雄激素性秃发关系密切。

Androgenetic alopecia （AGA）, the most common baldness,is a polygenic hereditary disease of unknown origin. It has been revealed that the pathogenesis of AGA is associated with androgen （especially dihydrotestosterone） and with mental factors. Dermal papilla cells （DPC）,which originate from fibroblasts,are mesenchyme cells of hair papilla. DPC express androgen receptors, secrete a variety of cell factors, induce hair follicle regeneration and play an important role in hair follicle cycle. In addition, DPC are concerned with the metabolism of androgen that can stimulate DPC from sensitive hair follicles to secrete soluble cell factors and result in baldness. Therefore, DPC have a close relationship with AGA.