新疆哈萨克族RGS2基因1891-1892del TC多态性与原发性高血压关系的研究

Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population

目的研究在新疆哈萨克族人群中G蛋白信号转导调节蛋白-2基因（regulator of G-protein signaling 2，RGS2）1891—1892del TC位点多态性与原发性高血压遗传易感性的关系。方法采用病例（444例）-对照（489例）方法进行关联分析，用TaqMan荧光实时定量PCR检测1891—1892del TC位点的基因型。结果1891-1892del TC在该人群男性中（OR=1．698，P=0．03）以及总体人群中（OR=1．32，P=0．044）与高血压病显著相关；ID＋DD基因型组的平均收缩压水平明显高于Ⅱ基因型组（P=0．04）；DD和ID基因型组的血清尿酸水平均高于Ⅱ基因型组（P〈0．01）。结论研究结果表明RGS2基因的D等位基因与新疆哈萨克族原发性高血压的遗传易感性相关，同时与血清尿酸水平升高相关。

Objective To investigate the association of the 1891-1892del TC polymorphism of regulator of G-protein signalling 2 （RGS2） gene with hypertension in Xinjiang Kazakh population. Methods The case-control study was performed in 444 cases and 489 controls. The genotypes of the individuals in the 1891-1892del TC locus were identified by TaqMan method. Results A significant association was observed between the1891 1892TC insertion/deletion polymorphism with hypertension in men （OR= 1. 698, P= 0.03） and in the total population （OR：1. 32, P=0. 044）. The mean systolic blood pressure and serum uric acid levels of the ID＋DD carriers were significantly higher than that of the Ⅱ carriers （adjusted, P= 0.04 and P〈0. 01）. Conclusion The results suggest that the D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene might be an independent risk factor for hypertension in Xinjiang Kazakhs; and the polymorphism may have some influence on serum uric acid level in this population.