摘要
非编码RNA是指除mRNA、tRNA和rRNA以外,不编码蛋白质的RNA分子。它们在细菌、真菌和哺乳动物等许多生物体的重要生命活动中发挥着极广泛的调控作用。近年来研究表明,非编码RNA既可作为癌基因,也可作为抑癌基因,对肿瘤的发生、发展产生重大的影响。同时,非编码RNA又有希望成为肿瘤诊断的标志物和肿瘤治疗的新靶点。作者综述了小干扰RNA和微小RNA等主要非编码RNA与肿瘤关系的最新研究进展。
Non-coding RNAs (ncRNAs) are RNA molecules that exclude mRNA, tRNA and rRNA, and do not code proteins, ncRNAs play a various roles in the regulation of important vital activities in many organisms such as bacteria, fungi and mammals. Recent researches have shown that ncRNAs, as oncogenes or tumor suppressor genes, have tremendous impacts on the occurrence and development of tumors. Meanwhile, ncRNAs have become a new type of tumor markers and new targets for cancer treatment. This review describes the research progresses of ncRNAs such as small interference RNA and microRNA, and their roles in carcinogenesis.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2010年第1期56-59,共4页
Chinese Journal of Medical Genetics
基金
国家自然科学基金(30872420)
浙江省科技攻关项目(2008C33020,2008F70052)
浙江省自然科学基金(Y207240,Y207244)
宁波市自然科学基金(2009A610134,200901A6010024)
志谢 衷心感谢广东医学院中美肿瘤研究所所长何志巍教授对本文的悉心指导和认真修改