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柚皮素对激光诱导的大鼠脉络膜新生血管的抑制作用 被引量:8

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摘要 糖皮质激素和血管内皮生长因子(VEGF)拮抗剂眼内注射是目前脉络膜新生血管(CNV)药物治疗的主要途径,但前者会导致眼压升高,后者需要反复眼内注射,且长期生物安全性尚待进一步观察。因此,多途径寻找安全有效的防治CNV药物有重要意义。研究表明,炎症过程在CNV的发生、发展中起了重要作用。因此,我们采用激光诱导的棕色挪威(BN)大鼠CNV模型,观察具有抗炎作用的中药单体柚皮素对CNV形成的抑制作用,并对其作用机制进行了初步研究。现将结果报道如下。
作者 吉洁 徐新荣
出处 《中华眼底病杂志》 CAS CSCD 北大核心 2010年第1期79-81,共3页 Chinese Journal of Ocular Fundus Diseases
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