脂肪乳剂在极低出生体重儿早期肠外营养中的作用

The effect of lipid emulsion in early parenteral nutrition on very low birth weight infants

目的:探讨早期肠外营养(EPN)对极低出生体重儿(VLBW)体重增长的影响和不良反应发生情况。方法:将体重<1 500 g的极低体重儿随机分为治疗组(40例)和对照组(38例)。治疗组病儿出生后24 h即应用含脂肪乳的PN,并辅以少量的胃肠道喂养和非营养性吸吮。对照组应用不含脂肪乳的PN,其他同治疗组。10 d后,检测体重变化、相关生化指标和并发症情况。结果:治疗组病儿每天体重增长幅度明显高于对照组,未增加病儿患氮质血症、高胆红素和胆汁淤积等的危险性。两组病儿并发症的发生率无显著性差异(P>0.05)。结论:应用脂肪乳剂EPN,能缩短病儿平均住院时间,促进体重增长。

Objective： To explore the influence of lipid emulsion of early intravenous nutrition on gain in weight and observe the side effect in very low birth weight（VLBW） infants.Methods： The infants with birth weight below 1 500 g were randomly divided into the treatment group and the control group.The treatment group received intravenous nutrition with fat emulsion within 24 hours after birth,and the control group received intravenous nutrition without fat emulsion.The weight,biochemical parameters and complication were observed after 10 days.Results： The daily weight gain of treatment group was significantly higher than the cotrol group.The risks of azotemia,high bilirubin and cholestasis were not increased in treatment group.The incidences of complication between the two groups showed no significant difference（P〉0.05）.Conclusion： The use of fat emulsion in early intravenous nutrition can shorten the average hospital stay,promote the weight gain,and is safe.