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SIRT1对高糖刺激肾小球系膜细胞叉头转录因子1和p27^kip表达的影响 被引量:3

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摘要 SIRT1是酵母染色沉默信息调节因子2的哺乳动物同源体,是一种依赖炯酰胺腺嘌呤二核苷酸的组蛋白去乙酰化酶活性的多功能转录调节因子,在体内参与调控哺乳动物细胞寿命的不同信号通路及糖代谢、胰岛素分泌等多条代谢途径。研究发现激活SIRT1对糖尿病及其并发症有防治作用,是重要靶点之一。
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2010年第1期57-58,共2页 Chinese Journal of Nephrology
基金 湖北省教育厅科研项目(B20092802)
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参考文献4

  • 1Orimo M, Minamino T, Miyauchi H, et al. Protective role of SIRTI in diabetic vascular dysfunction. Arterioscler Thromb Vasc Biol, 2009, 29: 889-894.
  • 2Sharma S, Anjaneyulu M, Kulkami SK, et al. Resveratrol, a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats. Pharmacology, 2006, 76: 69-75.
  • 3罗萍,许钟镐,孙广东,张冬梅,苗里宁,李才.ERK1/2对高糖刺激肾小球系膜细胞葡萄糖转运蛋白1和p27^(Kip1)表达的作用[J].中华肾脏病杂志,2006,22(9):569-571. 被引量:7
  • 4Nakae J, Cao Y, Daitoku H, et al. The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1- dependent transcriptional activity. J Clin Invest, 2006, 116: 2473-2483.

二级参考文献7

  • 1Heilig CW,Liu Y,England RL,et al.D-glucose stimulates mesangial cell GLUT1 expression and basal and IGF-1-sensitive glucose uptake in rat mesangial cells:implications for diabetic nephropathy.Diabetes,1997,46:1030-1039.
  • 2Heilig CW,Brosius FC,Cunningham C.Role for GLUT1 in diabetic glomerulosclerosis.Expert Rev Mol Med,2006,8:1-18.
  • 3Haneda M,Araki S,Togawa M,et al.Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions.Diabetes,1997,46:847-853.
  • 4Santalucia T,Sanchez-Feutrie M,Felkin LE,et al.Phenylephrine requires the TATA box to activate transcription of GLUT1 in neonatal rat cardiac myocytes.J Mol Cell Cardiol,2005,38:677-684.
  • 5Wolf G,Schanze A,Stahl RA,et al.p27Kip1 Knockout mice are protected from diabetic nephropathy:evidence for p27Kip1haplotype insufficiency.Kidney Int,2005,68:1583-1589.
  • 6Xu ZG,Yoo TH,Ryu DR,et al.Angiotensin Ⅱ receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli.Kidney Int,2005,67:944-952.
  • 7李颖健,刘志红,刘栋,朱加明,郭啸华,黎磊石.葡萄糖转运蛋白1基因转染对系膜细胞功能的影响[J].中华肾脏病杂志,2000,16(6):357-362. 被引量:2

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